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NMN

Other

Also known as: Nicotinamide Mononucleotide, β-NMN

NMN is a direct precursor to NAD+, a coenzyme central to energy metabolism, DNA repair, and sirtuin activation. NAD+ levels decline with age, and NMN supplementation aims to restore them to support cellular resilience and healthspan.

Best Timing

Take in the morning — NAD+ follows a circadian rhythm peaking during the day. Food does not appear to significantly affect absorption.

Absorption

Oral NMN is absorbed and rapidly converted to NAD+ in tissues. Sublingual use is popular but not proven superior in head-to-head trials.

Health Goals
🧬Longevity⚡Energy💪Muscle
Who Should Take This
Elderly (60+)Athletes
  • Raises NAD+ levels in blood and tissues
  • May improve mitochondrial function and aerobic capacity
  • Supports sirtuin-mediated DNA repair and stress resistance
  • Early trials show improvements in muscle insulin sensitivity and physical performance in older adults
  • May support vascular endothelial function
General longevity / NAD+ support250–500 mg

Daily

Morning, with or without food

Research-level dosing600–1,000 mg

Daily

Doses used in recent human trials

  • -β-NMN capsules – standard oral form
  • -Sublingual NMN – may bypass first-pass metabolism
  • -Nicotinamide Riboside (NR) – related NAD+ precursor, alternative product
Trace amounts in broccoli, cabbage, cucumberEdamame and avocadoDietary intake is too low to affect NAD+ meaningfully — supplementation is required
QuercetinSynergy

Quercetin inhibits CD38, an enzyme that degrades NAD+, potentially extending NMN's effect.

NACSynergy

Glutathione and NAD+ are the two main cellular redox systems — support both for resilience.

CoQ10Synergy

Complementary mitochondrial support — NAD+ for oxidative metabolism, CoQ10 for electron transport.

Alpha-Lipoic AcidSynergy

Works alongside NAD+-dependent enzymes in mitochondrial energy metabolism.

Read research on NMN

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