DosePhi
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Vitamin K2

Vitamins

Also known as: Menaquinone, MK-7, MK-4

Vitamin K2 activates proteins that direct calcium into bones and teeth, and away from soft tissues like arteries. It is critical for bone and cardiovascular health, and is commonly under-consumed in Western diets.

Best Timing

Take with a fat-containing meal, ideally alongside Vitamin D3.

Absorption

Fat-soluble. MK-7 has superior bioavailability and longer half-life compared to MK-4.

Health Goals
❤️Heart🦴Joints🧬Longevity
Who Should Take This
Elderly (60+)WomenKeto/Low-Carb
  • Directs calcium into bones and teeth
  • Prevents arterial calcification
  • Supports bone density and reduces fracture risk
  • May support dental health
  • Works synergistically with Vitamin D3
  • May reduce risk of heart disease
General health (MK-7)100–200 mcg

Daily

Bone health / osteoporosis (MK-7)200–300 mcg

Daily

Bone health (MK-4)15–45 mg

Daily in divided doses

Much higher doses required than MK-7

Paired with Vitamin D3100 mcg MK-7 per 2,000 IU D3

Daily

  • -MK-7 – long half-life (~72 hours), most studied
  • -MK-4 – short half-life, high doses needed, rapidly absorbed
Natto (fermented soybeans) – richest sourceHard cheeses (Gouda, Brie)Egg yolks (pasture-raised)LiverFermented foods
Vitamin D3Synergy

D3 increases calcium absorption; K2 ensures it goes to bones, not arteries. Essential pairing.

CalciumSynergy

K2 activates osteocalcin, which binds calcium into the bone matrix.

Vitamin ASynergy

Vitamins A, D, and K2 work together as a synergistic triad for bone and immune health.

A calcium-dependent mechanism for K2 stimulation of bone formation

Knapen MH, Drummen NE, et al. - Thrombosis and Haemostasis (2015)

MK-7 at 180 mcg/day for 3 years significantly improved bone strength and reduced loss of vertebral height.

Menaquinone-7 supplementation and arterial stiffness

Knapen MH, Braam LA, et al. - Thrombosis and Haemostasis (2015)

180 mcg MK-7 daily for 3 years significantly decreased arterial stiffness in healthy postmenopausal women.